After adjusting for potential confounders with less than 10% of missing data (i.e., age, gender, leukocytes and neutrophils count, hemoglobin, platelets, C reactive protein) and also comorbidities (hypertension, diabetes mellitus, chronic heart diseases, chronic lung diseases, chronic kidney disease, cancer), NEU-SFL values belonging to the 4th quartile of its distribution remained an independent predictor of death (adjusted OR, 2.88; 95% CI, 1.86–4.46, p < 0.0001) (Table 2), together with increasing ages and male sex. This evidence concerns the gene CRP and Hypertension.