Numerous clinical andin-vitro studies have investigated the role of neutrophil activation in CAD and have reported evidence of exaggerated systemic and local activation of neutrophils in acute coronary syndromes.66 Activated neutrophils infiltrate and aggregate at lesion sites, release proteolytic enzymes (elastase, MPO [myeloperoxidase]), ROS, etc which can directly induce endothelial and vasculature damage and exert thrombotic/hemostatic effects.67 This evidence concerns the gene MPO and acute coronary syndrome.