ORM1 and type 2 diabetes mellitus: Also, alpha-1-acid glycoprotein (AGP), an acute-phase protein, usually elevated in T2DM has been implicated in the impairment of neutrophil migration and chemotaxis in animal models.7 Further, resistin, a cysteine-rich protein hormone secreted by macrophages and elevated in T2DM patients, has shown to decrease fMLP (proinflammatory peptide formyl-methionyl-leucyl-phenylalanine)-induced neutrophil chemotaxis in vitro (inhibition of PI3K [phosphatidylinositol-3 kinase] pathway activation) and PMA (phorbol 12-myristate 13-acetate)/Ecoli induced oxidative burst.