ITGAM and chronic obstructive pulmonary disease: A study found no alteration in neutrophil activation markers (CD11b, CD66b, CD62L) but reported a downregulated expression of surface chemokine receptors for CXCL8, CXCR2.128 Another study also reported unaltered neutrophil activation markers CD11b and CD66b and subtle reductions in the surface expression of CXCR2 (a chemokine receptor), CD10 (a common maturity marker) and CD62L (an adhesion molecule) in neutrophils from patients with COPD.129