A study on circulating neutrophils of COPD patients reported enhanced respiratory burst and neutrophil response to proinflammatory stimulation.118 Another study reported increased CD11b and decreased CD62L expression in circulating as well as airway neutrophils of chronic smokers with and without COPD which indicates a higher state of priming.119. The gene discussed is ITGAM; the disease is chronic obstructive pulmonary disease.