Moreover, due to environmental (drugs, parental glucose infusion, sepsis, intrauterine growth restriction) and intrinsic factors (e.g. alteration of hormonal regulation with reduced insulin production and reduced suppression in hepatic glucose production), preterm infants have an increased risk of hyperglycemia (99–102), which is inversely correlated to gestational age (103). The gene discussed is INS; the disease is Sepsis.