WNT16 and osteoarthritis: While previous work indicated that there was no association between Wnt16 gene polymorphisms and osteoarthritis (OA) (90), recently, two SNPs of the Wnt16 gene (rs2707466 and rs2908004) known to be associated with BMD have been implicated in the hip and knee OA phenotypes in Caucasian patients in a sex-dependent manner (91).