PRDX members, including Prdx1 (6), Prdx2 (7), Prdx3 (8), Prdx4 (9) and Prdx6 (10, 11), were reported to be overexpressed in obesity, type 2 diabetes mellitus (T2DM) and atherosclerosis (12). The gene discussed is PRDX4; the disease is type 2 diabetes mellitus.