PRDX1 and obesity due to melanocortin 4 receptor deficiency: PRDX members, including Prdx1 (6), Prdx2 (7), Prdx3 (8), Prdx4 (9) and Prdx6 (10, 11), were reported to be overexpressed in obesity, type 2 diabetes mellitus (T2DM) and atherosclerosis (12).