Eosinophils defend the body against parasitic, bacterial, viral, and fungal infections through mediators such as major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN) in the presence of antibodies and complement (Kanda et al., 2020). This evidence concerns the gene RNASE3 and fungal infectious disease.