The addition of LR increased the expression of GLUT4 mRNA and protein in a concentration-dependent manner, which was consistent with Ji et al. [15] who found that LR upregulated the expression of GLUT4 and improved IR in type 2 diabetes skeletal muscle through PTP1B and PI3K/Akt2 signal pathways. The gene discussed is PTPN1; the disease is type 2 diabetes mellitus.