Reduced expression of NuRD components in Hutchinson‐Gilford progeria syndrome (HGPS, OMIM 176670), HGPS‐derived cells and those from older donorsReduced HDAC1 activity (encoded by Hsa‐HDAC1) was also found (the NuRD chromatin remodeling complex that includes HDAC1 and HDAC2), suggesting that the mechanism could also be related to histone acetylation. The gene discussed is HDAC2; the disease is Hutchinson-Gilford progeria syndrome.