The Hutchinson‐Gilford progeria syndrome (HGPS, https://www.omim.org/entry/176670), which is characterized by an extreme premature aging phenotype, is caused by various germline mutations in LMNA, suggesting a mechanistic link between nuclear architecture, heterochromatin, and aging.129, 130. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.