On the other hand, miR-152 is involved in regulating phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular regulated protein kinases (ERK)/NF-κB signaling pathways, while miR-578 is potentially involved in angiogenesis of BRCA-related breast cancer 65, 66. The gene discussed is AKT1; the disease is breast carcinoma.