Meanwhile, in addition to GLUL, we also found several potential candidate genes showing high expression in tamoxifen-treated recurrence breast cancer patients, which may serve as ideal targets for the treatment of breast cancer (Figure 6), including ZNF148 79, VPS4A 80, SPN 81, PTPN9 82, APEX 83, RAE1 84, CCT7 85, USP2 86, and RAGA 87. The gene discussed is SPN; the disease is breast cancer.