In previous literature, hsa-miR-1323 widely regulate cancer progression and radiotherapy effects 58, miR-711 regulates NCI-N87 and SNU-1 cells gastric cancer lines progression by targeting CD44 59, miR-4287 is a critical molecule in osteoarthritis development 60, miR-650 inhibits the progression of glioma by targeting FAM83F 61. The gene discussed is CD44; the disease is osteoarthritis.