CXCL8 and Keratoconjunctivitis sicca: In contrast with normal people, the chemokine IL-8/CXCL-8 was found significantly elevated in all kinds of dry eye patients tear, therefore, IL-8/CXCL-8 may be located in the critical position in the pathogenesis of dry eyes and strongly affects ocular discomfort symptoms 22, 35.