In addition, KEGG enrichment analysis depicted that the 60 candidate targets were mainly enriched in inflammation and infection-related pathways, as well as NF-kappa B signaling pathway and AGE-RAGE signaling pathway in diabetic complications, etc. At the same time, it could be seen that the number of pathway enrichment from high to low was RELA, FOS, and TLR4 pathway (Figure 1(h)). Here, TLR4 is linked to infection.