For example, miR-31-5p is a regulator of CMH in COPD, miR-145 downregulates MUC5AC to alleviate airway remodelling and targets EGFR to inhibit the cytokine expression, and miR-330 regulates interleukin-13-induced MUC5AC secretion by targeting Munc18b in human bronchial epithelial cells [12–14]. Here, MUC5AC is linked to chronic obstructive pulmonary disease.