Mutations and loss of CIC have been reported to promote the progression of various cancers via derepression of cancer-associated CIC target genes, including polyomavirus enhancer activator 3 (PEA3) group genes (ETS variant transcription factor 1 [ETV1], ETV4, and ETV5) (Kawamura-Saito et al., 2006; Choi et al., 2015; Okimoto et al., 2017; Kim et al., 2018; Bunda et al., 2019; Lee et al., 2020). The gene discussed is CIC; the disease is cancer.