There is also evidence that activated Ca2+-calcineurin-NFAT4 signaling promotes stemness in oral squamous cell carcinoma cells (Lee S. H. et al., 2019), as well as cell migration and angiogenesis in breast cancer (Liu et al., 2018b) and colon cancer (Liu et al., 2018a). This evidence concerns the gene NFATC3 and colonic neoplasm.