TRPV4 was elevated in colon cancer, basal-like breast cancer and tumor-derived endothelial cells, but was downregulated in keratinocytes in non-melanoma skin cancer (Nilius et al., 2007; Prevarskaya et al., 2007; Fiorio Pla et al., 2012; Xie et al., 2017; Zhang et al., 2018; Liu et al., 2021). The gene discussed is TRPV4; the disease is colonic neoplasm.