To elucidate the biological role of CCDC45 in HCC, we queried the LinkedOmics database and found that CCDC45 not only had a significant impact on the prognosis of HCC patients but that most of the genes that coexpressed with CCDC45 in HCC also significantly correlated with the prognosis of HCC patients. The gene discussed is CEP95; the disease is hepatocellular carcinoma.