Compared with WT mice, the levels of sphingosine, sphinganine, 3-ketosphingosine, sphingosine-1-phosphate (S1P), sphinganine-1-phosphate and sphingomyelins (SM) were significantly increased in APP/PS1 mice, while ceramides presented both negative and positive associations with AD. The gene discussed is PSEN1; the disease is Alzheimer disease.