Herein, an ultra-high-performance liquid chromatography-mass spectrometry- (UHPLC-MS-) based metabolomic and lipidomic profiling analysis was performed in the plasma of wild-type and amyloid precursor protein (APP)/presenilin-1 (PS1) double-transgenic mice, a prominent mouse model of AD. The gene discussed is PSEN1; the disease is Alzheimer disease.