RPS6KB1 and Alzheimer disease: Indeed, the levels of eukaryotic Initiative Factor 4E (eIF4E) (Li et al., 2005), phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) (Li et al., 2005), ribosomal protein S6 kinase beta-1 (p70S6K) (Sun et al., 2013), Akt activation (Griffin et al., 2005) and mTOR phosphorylation (at Ser248) are considerably increased in AD-affected brains.