Likewise, in hippocampus regions of AD brains, heavy levels of 8-hydroxyguanine were also reported (Lovell and Markesbery, 2007; Siman et al., 2015) investigated the selective expression and toxicity of diseased tau by a viral vector approach in the mouse lateral perforant pathway to understanding the activity of rapamycin and its neuroprotective effect. The gene discussed is MAPT; the disease is Alzheimer disease.