Mutations of KV2.1 channels underlie epileptic encephalopathies, infantile epilepsy, autism and other neurodevelopmental disorders in identified individuals (Torkamani et al., 2014; Saitsu et al., 2015; Thiffault et al., 2015; Calhoun et al., 2017). Here, KCNB1 is linked to Epileptic encephalopathy.