Neutrophils can produce and release active cytokines, such as IL6-1, IL-6 and vascular endothelial growth factor (VEGF), which alter the balance of inflammation and anti-inflammation in the tumor microenvironment, making inflammatory response biomarkers promising prognosis factors in renal cell cancer (RCC) (Fox et al., 2013). The gene discussed is VEGFA; the disease is neoplasm.