Neutrophils can produce and release active cytokines, such as IL6-1, IL-6 and vascular endothelial growth factor (VEGF), which alter the balance of inflammation and anti-inflammation in the tumor microenvironment, making inflammatory response biomarkers promising prognosis factors in renal cell cancer (RCC) (Fox et al., 2013). This evidence concerns the gene IL6 and renal cell carcinoma.