Emodin blocks agonist-induced and pressure overload-mediated myocardial hypertrophy (Evans et al., 2021) and plays an important role in alleviating myocardial hypertrophy by regulating the mitochondrial Sirt3 signaling pathway (Gao et al., 2020; Guo et al., 2020). This evidence concerns the gene SIRT3 and cardiac hypertrophy.