Meanwhile, bioinformatics predicted that wogonin could enhance gemcitabine sensitivity of pancreatic cancer by inhibiting AKT2, CCL2, HSP90AA1, PDE5A, and activating PTGS1, BCHE, SERPINB5, CA2, SRC, DGKA, HIF1A, PTGS2, ABCA1, DPYD, AKR1C3. The gene discussed is HIF1A; the disease is familial pancreatic carcinoma.