These fifteen DEGs, including AKT2, CCL2, HSP90AA1, PDE5A, PTGS1, BCHE, SERPINB5, CA2, SRC, DGKA, HIF1A, PTGS2, ABCA1, DPYD, and AKR1C3 were potential target of wogonin to enhance gemcitabine sensitivity in pancreatic cancer. Here, PTGS1 is linked to familial pancreatic carcinoma.