According to Okada et al., the removal of cholinergic cell groups in the basal forebrain cause an impairment of social behavior which was significantly reinstated by cholinesterase inhibitors, suggesting the critical role of cholinergic dysfunction in sociability deficits corelated with psychological and behavioral symptoms of dementia in AD (Okada et al., 2021). The gene discussed is BCHE; the disease is Alzheimer disease.