In particular, combination of certain somatic mutations (e.g., biallelic mutation of CEBPA, NPM1, FLT3-ITD, or TP53) and chromosomal alterations (including t(8; 21), inv(16), or alterations involving chromosome 7) can predict AML prognosis (Bataller A et al., 2022; Fu W, et al., 2022). Here, NPM1 is linked to acute myeloid leukemia.