EN1 and Parkinson disease: In fact, an age-related decline of FOXA2 protein levels was reported in mice, and a downregulation of FOXA1/2 and several putative FOXA targets, such as ALDH1A1, DAT, DDC, EN1, NURR1, and TH, was detected in the SNc of PD patients but not age-matched healthy controls (Domanskyi et al., 2014; Oh et al., 2015).