AGTR1 and Parkinson disease: A recent high-coverage single-nuclei RNA sequencing and spatial transcriptomic study confirmed that a SOX6+ mDA neuron subset (co-expressing the angiotensin II receptor type 1) located in the human vSNc is the population showing the largest decline in postmortem PD brains and the highest association with PD risk genes (Kamath et al., 2022).