FGFR1 and viral infectious disease: Nevertheless, signaling via the FGFR1 and MAPK/PI3K/AKT pathways was necessary for the sustained survival of mDA neurons in the adult rodent VM, as demonstrated by a reduction of mDA neuron numbers and striatal DA innervation after intranigral viral infection or transfection of a construct encoding a tyrosine kinase-lacking FGFR1 (Corso et al., 2005), in transgenic mice expressing this dominant negative (DN) FGFR1 in catecholaminergic neurons (Klejbor et al., 2006), and after treatment with an FGFR antagonist (Boshoff et al., 2018).