However, consensus exists that mouse Lmx1b/human LMX1B expression persists in these neurons throughout adulthood and during aging (Laguna et al., 2015; Doucet-Beaupre et al., 2016), although LMX1B appeared to be downregulated in nigrostriatal mDA neurons from PD patients (Laguna et al., 2015). This evidence concerns the gene LMX1B and Parkinson disease.