NR4A2 and Parkinson disease: NURR1 is probably the mDA-associated TF that has been explored most intensively in preclinical trials for mDA neuroprotection in PD, based on its ability to directly activate several genes involved in mDA identity and metabolism, and at the same time to convey anti-inflammatory properties to the rodent VM (Decressac et al., 2013; Dong et al., 2016).