Notably, AAV-mediated OE of NURR1 alone was not or only marginally protective for mDA neurons in this PD model or after striatonigral retrograde transport in the unilaterally 6-OHDA-lesioned rat (Hurtado-Lorenzo et al., 2004; Oh et al., 2015). The gene discussed is NR4A2; the disease is Parkinson disease.