Furthermore, previous works reported that the TrkB pathway was disturbed in fast muscles affected by ALS (Just-Borràs et al., 2019; Tosolini et al., 2022), while exercise, that improved mice phenotype (Deforges et al., 2009), reduced the molecular alterations (Just-Borràs et al., 2019, 2020). Here, NTRK2 is linked to amyotrophic lateral sclerosis.