In addition, Kang et al. discovered in a mouse model that PAD inhibition decreases the amount of IFN-β induced by stroke, a process that is mediated by STING; moreover, STING knockdown and IFN receptor-neutralizing antibody therapy decrease BBB disruption and enhance vascular plasticity (Kang et al., 2020). The gene discussed is STING1; the disease is Stroke.