Hou et al. found that supplementation with the NAD+ precursor nicotinamide riboside (NR) could stimulate mitophagy to reduce cytoplasmic DNA and the cGAS–STING signaling, thereby decreasing neuroinflammation and cellular senescence in the brains of AD mice (Hou et al., 2021). This evidence concerns the gene STING1 and Alzheimer disease.