G3BP1 and Aicardi-Goutieres syndrome: Liu et al. (2019) found that GTPase-activating protein SH3 domain-binding protein 1 (G3BP1, a protein known to regulate the RNA stress response) initiates cGAS to achieve effective DNA binding, and the targeted inhibition of G3BP1 could treat cGAS-mediated chronic inflammation in the cells of patients with AGS.