However, AEE treatment ameliorated the pathways of choline metabolism in cancer, glycerophospholipid metabolism, GnRH signaling pathway, fat digestion and absorption, sphingolipid signaling pathway, cAMP signaling pathway, NF-kB signaling pathway, Th1 and Th2 cell differentiation in Figure 5B. The gene discussed is NFKB1; the disease is cancer.