In liver lipidomics, AEE treatment ameliorated the pathways destroyed in the model group of choline metabolism in cancer, glycerophospholipid metabolism, GnRH signaling pathway, fat digestion and absorption, sphingolipid signaling pathway, cAMP signaling pathway, NF-kB signaling pathway, Th1 and Th2 cell differentiation. The gene discussed is GNRH1; the disease is cancer.