HMGCR and metabolic dysfunction-associated steatotic liver disease: In addition, we studied the effect of FBT on the cecal barrier and factors related to lipid synthesis in the cecum and liver of NAFLD mice and found that FBT could ameliorate the cecal barrier and improve the mRNA expression of HMGCR, PPAR-γ and SCD-1 in the cecum and liver of NAFLD mice.