Although pediatric colorectal cancer (CRC) is a very rare disease, with a reported incidence of 1 in 1 million, its biology has notable differences from adult CRC; as such, this case may be further evidence of a role for TDG and active demethylation as a cancer phenotype modifier, as opposed to a singular tumor suppressor role seen with TET2. The gene discussed is TDG; the disease is cancer.