Compared to HC, SSc patients showed no substantial differences in the percentage of CD20+ B lymphocytes (9.6% vs 9%), CD3+ lymphocytes (74.6% vs 73.2%), CD3+CD4+ T helper lymphocytes (48.4% vs 45.7%), CD3+CD8+ T cytotoxic lymphocytes (23% vs 23.2%). The gene discussed is CD4; the disease is systemic sclerosis.