TMEM59L and cancer: The TMEM59L gene was hypermethylated in most cancers, including COAD (Figure 7B), BRCA (Figure 7C), PAAD (Figure 7D), HNSC (Figure 7E), BLCA, UCEC, KIRC, and LUSC, whereas it was hypomethylated in KIRP, LUAD, and THCA (P < 0.05, Figure S5).