TMEM59L and cancer: In the current study, the expression of TMEM59L was closely related to homologous recombination deficiency status in most tumors (Figure 8C), and further loss of heterozygosity analysis showed a significantly positive association between loss of heterozygosity status and TMEM59L expression in several cancers, such as COAD, COADREAD, LAML, KIRP, PRAD, HNSC, LIHC, TGCT, and BLCA but a negative association with GBM, GBMLGG, LUAD, BRCA, SARC, and THCA (Figure 8D).