Subsequently, a pan-cancer analysis demonstrated that TMEM59L expression was decreased across most cancer types, such as GBM, GBMLGG, KIRP, COAD, KICH, KIRC, LGG, KIPAN, COADREAD, STAD, UCEC, READ, STES, and BLCA (Figure 1B). The gene discussed is TMEM59L; the disease is glioblastoma.