TMEM59L and cancer: Figure 6B showed that TMEM59L expression was evidently negatively correlated with IPS in several types of cancers, including GBMLGG, LGG, OV, CESC, KIRC, SKCM, KIRP, and KIPAN. Moreover, IPS analysis demonstrated that TMEM59L expression was positively associated with immune checkpoints (CP) and suppressor cells (SCs) but was negatively correlated with MHC, average Z-score (AZ), and effector cells (ECs) in most tumors, all the p-values are less than 0.05.