TMEM59L also showed a negative correlation with tumor mutational burden (TMB) in many cancers, such as HNSC, LUAD, LIHC, KIRC, BRCA, THCA, BLCA, KIRP, LGG, ESCA, PAAD, UCEC, and STAD and a negative correlation with microsatellite instability (MSI) in UCEC, ACC, ESCA, LAML, and STAD, which suggest that TMEM59L may reflect cancer immunogenicity in these cancer types (Figures 6D–E and Table S3). This evidence concerns the gene TMEM59L and cancer.