These results indicated that Cxcl16-Cxcr6, Ccl6-Ccr2 and Ccl5-Ccr5 might play a role in the pathogenesis of schistosomiasis associated liver fibrosis and interrupting those signaling pathways could help to alleviate hepatic fibrosis. This evidence concerns the gene CXCR6 and Hepatic fibrosis.