METTL3 and cancer: We evaluated m-6-A modified protein, which showed IMPDH1 was closely related to m-6-A related regulatory proteins in pan-cancer (Figure 13A), and we focused on evaluating the association of IMPDH1 with the top four proteins: YTHDF1, ALKBH5, YTHDF2, METTL3 in HCC (Figures 13B-E), indicating a strong relationship.