ALKBH5 plays an immunomodulatory role in melanoma, colorectal cancer and other tumors, not only regulating Mct4/Slc16a3 molecules related to tumor survival, metastasis and metabolism, but also affecting the number of tumor-infiltrating Treg cells and bone marrow derived inhibitory cells (MDSC) (19). The gene discussed is SLC16A3; the disease is neoplasm.