In a study of NSCLC, YTHDF1 and YTHDF2 were associated with a good prognosis of NSCLC patients, and down-regulation of YTHDF1 and YTHDF2 could up-regulate the expression of PD-L1 and reverse the tumor suppressive microenvironment (20). The gene discussed is YTHDF2; the disease is non-small cell lung carcinoma.