IMPDH1 and cancer: It has been reported that increased IMPDH1 expression promotes the formation of cytosine, thereby facilitating the consumption of guanine nucleotides, which is associated with uncontrolled proliferation, suggesting that IMPDH1 may influence the occurrence and development of malignant tumors (23), whereas there are few studies on the specific functions and potential mechanism of IMPDH1 affecting tumors, especially from the perspective of pan-cancer.