Our previous studies of acute immune responses following Vibrio cholerae infection in adults showed that vibriocidal, anti-CtxB, anti-TcpA, anti-LPS, and anti-OSP antibody responses are increased by day 7 after infection; while some of these antibody responses last longer than others, all fall back to baseline levels in the blood within 3-12 months after infection (14, 21, 22). The gene discussed is CLDN11; the disease is infection.