Following cholera, patients develop antibody responses to the sialidase produced by Vibrio cholerae. Here, we measured anti-sialidase IgA, IgG, and IgM immune responses in children and adults after natural cholera infection out to 540 days following infection and their association with other immunological parameters, nutritional status, and parasitic co-infection. The gene discussed is CD40LG; the disease is vibrio infectious disease.