Analysis of the CGGA-325, CGGA-693 datasets and TCGA datasets showed that PLK1 mRNA levels in the glioma patients with wild-type IDH and chromosomal 1p/19q non-codeletion were significantly higher (Supplementary Figures 2D-E), however, there is no significantly difference in the glioma patients with MGMT promoter methylation in CGGA datasets (Supplementary Figure 2F). This evidence concerns the gene PLK1 and central nervous system cancer.