used cationic lipid NPs to concurrently encapsulate STAT3 siRNA (siSTAT3) and TNF-α siRNA (siTNF-α) and demonstrated that these NPs could synergistically alleviate the skin lesion symptoms of psoriasis via inhibiting the expression of STAT3, TNF-α, and IL-23 (79). This evidence concerns the gene TNF and psoriasis.