TNF and psoriasis: prepared the nanocomplexes polyphenols-rich natural extracts (Cornus mas, CM) and Ag NPs (Ag-NPs-CM) or AuNPs (Au-NPs-CM), and demonstrated that these NPs can reduce the secretion of pro-inflammatory factors (e.g., IL-12 and TNF-α) in psoriasis by blocking of the NF-κB signaling pathway in macrophages (88).