GRN and Alzheimer disease: Genetic mutations or polymorphisms in GRN have been associated with several neurodegenerative diseases, including FTD, AD, and PD (16), and the protein it encodes, PGRN, is involved in regulating key inflammatory responses, including cytokine release and phagocytosis (6), thereby positioning GRN as a candidate gene to be investigated in the context of inflammation and neurodegeneration.