HGBL includes two types: high-grade B-cell lymphoma, accompanied by MYC and Bcl-2 and/or Bcl-6 rearrangement (HGBLR), and high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS), this type has a low incidence and is clinically rare (1, 3–5). This evidence concerns the gene BCL2 and high grade B-cell lymphoma.