Overexpression of Pyruvate dehydrogenase kinase 1 (PDK1) in OC cells impaired IFN-γ secretion in CD8+ T cells by upregulating PD-L1, and an increase in intra-tumor of IFN-γ was observed with DCA (a PDK inhibitor) and anti-PD-L1 antibodies (23). This evidence concerns the gene PDK1 and neoplasm.