BRCA1-deficient OC cells underwent chromatin reorganization and transcriptional reprogramming, a process that caused sensitization of the dsDNA-sensing pathway and excessive accumulation of cytoplasmic dsDNA, which then provoked an IFN response via the STING pathway, an inflammatory state that can aid in the recruitment of T cells and activation of DCs in tumor (30, 31, 66). Here, IFNA1 is linked to neoplasm.