SARS-CoV-2 infection can result in multiple cytokines expression including IL-1β, which plays a key role in the pathogenesis of virus infection associated ALI/ARDS, mediating acute proinflammatory cascade after infection and therefore leading to a series of proinflammatory responses including the activation of NLRP3 (12, 46). The gene discussed is NLRP3; the disease is viral infectious disease.