A total of 12 clusters, each having silhouette value higher than 0.7, were synthesized based on the co-cited references and numbered from 0 to 11 by size: 0, severe COVID-19; 1, dual inhibitor PTUPB; 2, virus infection; 3, mechanical ventilation; 4, lung diseases; 5, domain-containing pattern recognition receptor; 6, organ distribution; 7, inhibiting NLRP3 inflammasome activation; 8, damage-associated molecular pattern; 9, asiatic acid; 10, perforation-induced acute lung injury; and 11 inhibiting NLRP3 inflammasome-mediated pyroptosis. This evidence concerns the gene NLRP3 and COVID-19.