Analysis of IL-8 levels in the supernatant of heme treated SCA-hiPSC-ECs and WT-hiPSC-ECs also showed significantly lower secretion of IL-8 (P<0.01) from heme treated SCA-hiPSC-ECs (Figure 2J). The gene discussed is CXCL8; the disease is autosomal dominant cerebellar ataxia.