GSTM1 and malaria: Based on let-7 miRNAs’ well-established role in inducing erythropoiesis (56), as well as the significant positive correlation between exosomal let-7i-5p and Hb abundance in positive malaria patients, our data suggest a novel feedback loop in which anemic crisis due to RBC lysis causes the release of EC derived-exosomal let-7i-5p as a compensatory mechanism to induce erythropoiesis (Figures 2E-H).