In post-hepatitis HCC patients, a higher frequency of peripheral IL-10+ CD19+CD24+hiCD38+hi Bregs was found compared to patients with chronic HCV (Hepatitis C Virus), HCV-related liver cirrhosis, or healthy controls and was positively correlated with CD4+FoxP3+ Tregs and serum IL-10, IL-35 levels (111). This evidence concerns the gene IL10 and Hepatitis.