However, major studies to characterize IL-10+ Bregs have been conducted in the context of autoimmunity; their relevance has been found in several autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), atrioventricular septal defect (AVSD), and Marinesco-Sjögren syndrome (MSS) (19). This evidence concerns the gene IL10 and rheumatoid arthritis.