SLC7A5 and neoplasm: Moreover, large neutral amino acid transporter 1 (LAT1 or SLC7A5), the primary transporter of branched-chain amino acids (BCAAs) that are not synthesised in the body, is also overexpressed in lung cancer, glioblastoma and the blast phase of chronic myeloid leukaemia (98), providing the nutrients necessary for tumor growth (101).