In BC and high-grade bladder cancer, HIF-1α upregulates the expression of 6-phosphofructokinase/fructose-2,6-bisphosphatase (PFKB) 3 and 4, and controls the overall glycolysis rate by modulating the activity of phosphofructokinase 1 (PFK1) (95). Here, PFKFB3 is linked to breast cancer.