Downregulates GLUT1 expression in CRC (235), Inhibits glucose uptake in cells preferentially expressing GLUT1 or GLUT4 and inhibits active transport of glucose into cells by SGLT1 and SGLT2 in LC (382–385), Inhibit glucose reabsorption in the kidney in BC (386). The gene discussed is SLC5A1; the disease is colorectal carcinoma.