A similar decrease in serum MBL levels was found in the medium MBL expressing genotypes, where MBL levels decreased over the 5-year follow-up from 417 μg/L (IQR 265;518) to 295 μg/L (IQR: 147;352) for patients with T2D (p<0.001) and 347 μg/L (IQR 234;545) to 316 (IQR 197;427) in the healthy control subjects (p=0.003) (Figure 2B). This evidence concerns the gene MBL2 and type 2 diabetes mellitus.