To get a focused starting point regarding the overall contribution of IκBNS in the transcriptional regulation of acute inflammatory responses in vivo, we performed unbiased transcriptional profiling of whole livers from IκBNS+/+ and IκBNS-/- mice directly prior (day 0) and at different times (day 2, day 3 and day 4) post infection. This evidence concerns the gene NFKBID and infection.