TPO and melanoma: For example, a patient with stage M1C melanoma (100 points) with normal LDH level (0 points), whose baseline FT3 is 2.25 pmol/L (78 points) and baseline A-TPO is 17.24 U/ml (0 points), has a sum score equal to 178, which corresponds to the foreseen survival probability of 1, 2, and 3 years of 69%, 44%, and 33%, respectively (Supplementary Table 2).