CD4 and neoplasm: Further expression of this protein can increase the frequency of NK cells as well as CD4+ and CD8+ T cells via increasing the delivery of intracellular antigen to the proteasome and the presentation of antigen, improving antitumor responses.[40] Interleukin (IL)‐12 is known as an effective anticancer cytokine involved in Th1 differentiation, T‐cell‐mediated tumor cell killing, and tumor angiogenesis inhibition.