IFNG and neoplasm: The mechanism of the antiangiogenic effects of oncolytic viruses is related to infection of both tumor cells and tumor endothelium, disrupting tumor vasculature.[33] However, some studies have proposed the theory that the induction of interferon‐γ (IFN‐γ)‐mediated immune responses can also be effective in inhibiting tumor angiogenesis.[34] Following inhibition of angiogenesis, these viruses cause hypoxia, and the tumor cells lack access to oxygen and nutrients, which ultimately reduces tumor growth and progression.[35, 36, 37]