In order to verify the expression levels of NEDD4L and STAT3 in glioma tissue, we performed immunohistochemical staining of NEDD4L and STAT3 on a commercially available glioma tissue chip, and found that NEDD4L expression level negatively correlates with STAT3 expression in glioma tissues, while the expression levels of these two genes are comparable in normal tissue (Figure 2(c) left panel). Here, NEDD4L is linked to central nervous system cancer.