ATXN2 and amyotrophic lateral sclerosis: 2020 reported 1.5% ALS cases harboring intermediate ATXN2 CAG repeats in Indian cohort.[43] An extensive study on SCA2 large normal /PMNA has been conducted in Cuba in 2001, to estimate the potential risk of abnormal CAG expansion in the descendant population.[41] In our study, we state PMNAs frequency in uncharacterized cases and in normal allele ATXN2 positive cases, correlates the high prevalence of SCA2 in India (Table 1).