Notably, TGFBR2+ NK cells were the most immunosuppressive population, since they had significantly lower expression of GZMB (p < 2.2e‐16) and PRF1 (p < 2.2e‐16) than KLRC1+ and KLRC2+ clusters (Figure S8e, Supporting Information), consistent with a recent study.[28] To determine the difference of NK cells between SCLC and NSCLC, we pooled the NK cell data from our SCLC dataset and a previously published NSCLC dataset (Figure 6c). Here, PRF1 is linked to non-small cell lung carcinoma.