Although they had relatively high expression of the cytotoxicity markers such as PRF1, GZMA, and GZMB except GZMK (Figure S8f,g, Supporting Information), NK cells in SCLC‐dominant subpopulation were most likely exhausted as they had high expression of TGFBR2 and low expression of KLRC2 (Figure 6f). The gene discussed is PRF1; the disease is small cell lung carcinoma.